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Public display of deposited theses

Presentació d'al·legacions a una tesi doctoral en el termini d'exposició pública

In accordance with the Academic Regulations for Doctoral Studies, doctors may request access to a doctoral thesis in deposit for consultation and, if there are, to send to the Permanent Commission of the Doctoral School the observations and allegations that they consider opportune on the content.

 

DOCTORAL DEGREE IN BIOMEDICAL ENGINEERING

  • NOLLA COLOMER, CARME: Anàlisi de patrons funcional i estructurals en la regulació del calci en les cèl·lules cardíaques
    Author: NOLLA COLOMER, CARME
    Thesis file: (contact the Doctoral School to confirm you have a valid doctoral degree and to get the link to the thesis)
    Programme: DOCTORAL DEGREE IN BIOMEDICAL ENGINEERING
    Department: Department of Automatic Control (ESAII)
    Mode: Temporary seizure
    Deposit date: 28/04/2021
    Deposit END date: 11/05/2021
    Thesis director: BENITEZ IGLESIAS, RAUL | MADSEN, LEIF HOVE
    Committee:
         PRESIDENT: MARTI BONMATI, JOAN
         SECRETARI: RODELLAR BENEDE, JOSE JULIAN
         VOCAL: GUERRA RAMOS, JOSÉ MARÍA
    Thesis abstract: In 2019 the data published by the World Health Organization showed that the cardiac ischemia is the first cause of death worldwide. These diseases are caused by irregularities of the contractile mechanism¿s function, starting from the cellular level till the organ dysfunction. To further understand the origin of these dysfunctions the thesis will focus on the molecular and cellular level. The small changes of the physiology at that level can lead to an anomalous cardiac electrophysiology.The previous studies suggest that there is a relation between the cardiac arrhythmia and the increase of global spontaneous calcium activity in cells. Ryanodine receptors have the major role in the calcium regulation. They release the calcium stored in the sarcoplasmic reticulum into the cytosol, then the calcium attaches to the actin and myosin to produce the mechanicalcontraction of the cell. The irregularities have been also related with an hyperphosphorylation of the ryanodine receptor channels, which increases the open probability of those.A large amount of data is generated in the biology and physiology laboratories, these have to be characterized, clustered and analysed to extract the meaning of the observed divergences. Thus, an interdisciplinary thesis has been developed in order to obtain experimental data with a confocal microscope in the laboratory and then creating new image processing tools in order to have an interpretable analysis of the experimental data.The main objective of the project is to characterize the spontaneous calcium activity through image processing tools and to observe its variations under different physiological conditions, such as the hiperphosphorylation of the ryanodine receptor channels or under cardiac arrhythmia conditions. The aim is to see how the modifications in the calcium activity affect to the propagation along the cell and report how the variations may lead to electric and contractile dysfunctions, and so, cause arrhythmias.To reach this goals the thesis is divided into three main sections or hypothesis:1. Experimental data acquisition, define the best image acquisition method in order to develop the studies of calcium images and proposal of methods to detect subcellular structures and spontaneous calcium events.2. Study of the calcium events substructure and the involved ryanodine receptor clusters. Comparison of the calcium activity properties of the cells at the basal level and under conditions of hyperphosphorylation or arrhythmia.3. Study of the physiological modifications in the calcium activity through different phosphorylation pathways.The results explain the ryanodine receptor clusters distribution through the cells, allow to have the localization of the channels and the calcium activity simultaneously and show relevant details such as, the increase in the duration of the events or the increase in the volume of calcium released when more ryanodine receptor clusters are co-activated. These modifications lead to have bigger events and, thus, more potentially dangerous because can depolarize the neighbouring cells. The parameters reflect the relationship between the phosphorylation of the ryanodine receptors and the spontaneous calcium release in the arrhythmogenesis process.

DOCTORAL DEGREE IN COMPUTER ARCHITECTURE

  • DAMICO, MARCO: Scheduling and resource management solutions for the scalable and efficient design of today's and tomorrow's HPC machines
    Author: DAMICO, MARCO
    Thesis file: (contact the Doctoral School to confirm you have a valid doctoral degree and to get the link to the thesis)
    Programme: DOCTORAL DEGREE IN COMPUTER ARCHITECTURE
    Department: (DAC)
    Mode: Normal
    Deposit date: 03/05/2021
    Deposit END date: 14/05/2021
    Thesis director: CORBALAN GONZALEZ, JULITA | JOKANOVIC, ANA
    Committee:
         PRESIDENT: BULL, JONATHAN MARK
         SECRETARI: UTRERA IGLESIAS, GLADYS MIRIAM
         VOCAL NO PRESENCIAL: RODRIGO ALVAREZ, GONZALO PEDRO
    Thesis abstract: In recent years, high-performance computing research became essential in pushing the boundaries of what men can know, predict, achieve, and understand in the experimented reality.HPC Workloads grow in size and complexity hand to hand with the machines that support them, accommodating big data, data analytic, and machine learning applications at the side of classical compute-intensive workloads. Simultaneously, power demand is hugely increasing, becoming a constraint in the design of these machines.The increasing diversification of processors and accelerators, new special-purpose devices, and new memory layers allow better management of these workloads. At the same time, libraries and tools are being developed to support and to make the most out of the hardware while offering standardized and straightforward interfaces to users and developers. Different scheduling and resource management layers are fundamental in organizing the work and the access to resources.This thesis focuses on the job scheduling and resource management layer. We claim that this layer needs research in the following three directions: awareness, dynamicity, and automatization. First, awareness of the hardware and applications characteristics would improve the configuration, scheduling, and placement of tasks. As a second point, dynamic systems are more responsive. They react fast to changes in the hardware, e.g.,in failure cases, and they adapt to application's requirements changes. Finally, automatization is the last direction. In our opinion future systems need to act autonomously. A system that keeps relying on user guidance is prone to errors and requires unnecessary user expertise.This thesis presents three main contributions contributing to fill those gaps. First, we developed DROM, a transparent library that allows parallel applications to shrink and expand dynamically in the computing nodes. DROM enables efficiently utilization of the available resources, with no effort for developers and users. We enabled vertical malleability, i.e., internal malleability in computing nodes, by including in DROM API and data structures that allow resource managers to control the number of threads and their pinning to computing cores at runtime. We measured a negligible overhead and we integrating DROM with OpenMPI, OmpSs, and MPI.As a second contribution, we developed a system-wide malleable scheduling and resource management policy that uses slowdown predictions to optimize the scheduling of malleable jobs. We called this policy Slowdown-Driven policy (SD-policy). SD-policy uses malleability and node sharing to run new jobs by shrinking running jobs with a lower slowdown, only if the new job has reduced predicted end time compared to the static scheduling. We obtained a very promising reduction in the slowdown, makespan, and consumed energy with workloads combining compute-bounded and memory-bounded jobs.Ultimately, we used and extended an energy and runtime model to predict the job's runtime and dissipated energy for multiple hardware architectures. We implemented an energy-aware multi-cluster policy, EAMC-policy, that uses predictions to select optimal core frequencies and to filter and prioritize job submissions into the most efficient hardware in case of heterogeneity. This is done automatically, reducing user's intervention and necessary knowledge. Simulations based on real-world hardware and workloads show high energy savings and reduced response time are achieved compared to non-energy-aware and non-heterogeneous aware scheduling.

DOCTORAL DEGREE IN ENVIRONMENTAL ENGINEERING

  • SALAS OLIVARES, HÉCTOR MANUEL: Eliminación de Blanqueadores Ópticos de aguas textiles residuales y reutilización de efluentes
    Author: SALAS OLIVARES, HÉCTOR MANUEL
    Thesis file: (contact the Doctoral School to confirm you have a valid doctoral degree and to get the link to the thesis)
    Programme: DOCTORAL DEGREE IN ENVIRONMENTAL ENGINEERING
    Department: (DECA)
    Mode: Temporary seizure
    Deposit date: 28/04/2021
    Deposit END date: 12/05/2021
    Thesis director: GUTIERREZ BOUZAN, M. DEL CARMEN | LOPEZ GRIMAU, VICTOR
    Committee:
         PRESIDENT: AVELAR GONZALEZ, FRANCISCO JAVIER
         SECRETARI: AMANTE GARCIA, BEATRIZ
         VOCAL NO PRESENCIAL: GARCIA FAYOS, BEATRIZ
    Thesis abstract: he textile industry consumes a large volume of water in various activities and is an importan! wastewater generator. Colorless dyes that emit fluorescence when exposed to UV light are used in the optical whitening process. They are known as optical brighteners (OB). The most common OB, currently used, has a stilbene-based structure. These emerging pollutants, with poor biodegradability, are not considered in the curren! legislation. Therefore, OB can go unnoticed in textile wastewater and reach the environment. In this research it was possible to quantify OB derived from stilbene with the UV-VIS spectrophotometric technique, which is a fast and inexpensive method. To evaluate how OBs affect biological treatment systems, a respirometry and toxicity study was carried out. The OBs evaluated did not present acule toxicity, at the concentrations that can be found in textile wastewater, but they can reduce bacteria! activity. The possibility of using a Moringa Oleifera coagulan! to eliminate these OBs was studied. This can be considered a zero cost coagulan! because it is a residue obtained from the extraction of moringa oil. In these synthetic water samples, the moringa coagulan! was able to eliminate up to 83% of OB ata settling time of 24 hours. Furthermore, alkaline effluents did not affect the efficiency of this coagulan! in removing BO. The efficiency of this coagulan! was compared against a traditional coagulan! and a commercial synthetic coagulan!. In the synthetic water samples with OB, the traditional aluminum sulfate coagulan! and the commercial coagulan! TIDEC removed 67% and 89% of the OB respectively ata settling time of 24h. On the other hand, the use of membrane technology for the removal of OB was studied. NF and UF membranes were used to treat synthetic waters with OB. In particular, one of the NF membranes used, H50, retained 85% of OB. However, this membrane requires an inlet effluent free of particulate matter. This can be achieved with a UF membrane, which can also remove a fraction of the OB. The combination of coagulation-flocculation and membrane technologies was tested by treating real whitening wastewater. This water contained residual elements of the textile fiber that affected the coagulan! performance. ¿espite this, it was possible to remove 85% of OB from these waters. ¿The water treated with the moringa coagulan! was recovered to evaluate the posibility of reusing it for new whitening processes. The whitened fibers reached an acceptable quality (DEcmc (2: 1) <1.5) for the textil e industry. On the other hand, when the treated water was reused combining coagulation-flocculation and membranes, an optimal quality was obtained (DEcmc (2: 1) <1) in the whitened fibers. Finally, it was studied whether these treatment techniques could be applicable to other textile effluents. Tests were carried out on textile wastewater with reactive dyes. The moringa coagulan!, removed 60% of the color from the residual dyeing bath and 80% of the color from the post-dyeing washing wastewater. The treated washing wastewater was reused for new textile . processes. lt was possible to obtain an optimal color quality (DEcmc (2: 1) < 1) these new dyed fibers. The reuse of water in textile whitening or dyeing processes saves 70% of the water, increasing the useful life of it. This would allow the conservation of fresh water sources, the reduction of the water footprint of the textile industry and promotes the circular economy. In addition, it can reduce the impact of residual salts from textile processes on biological treatment systems and the environment.

DOCTORAL DEGREE IN SIGNAL THEORY AND COMMUNICATIONS

  • GONZÁLEZ LÓPEZ, GISELLE: Wireless sensors embedded in high permittivity lossy media
    Author: GONZÁLEZ LÓPEZ, GISELLE
    Thesis file: (contact the Doctoral School to confirm you have a valid doctoral degree and to get the link to the thesis)
    Programme: DOCTORAL DEGREE IN SIGNAL THEORY AND COMMUNICATIONS
    Department: Department of Signal Theory and Communications (TSC)
    Mode: Article-based thesis
    Deposit date: 04/05/2021
    Deposit END date: 17/05/2021
    Thesis director: JOFRE ROCA, LUIS
    Committee:
         PRESIDENT: ANTONINO DAVIU, EVA
         SECRETARI: BROQUETAS IBARS, ANTONI
         VOCAL: LUXEY, CYRIL
    Thesis abstract: The design of wireless sensors for operation embedded in a medium with high losses creates a series of additional constraints that should be taken into consideration at design stage to enhance sensor performance. In such a medium, both the real and the imaginary part of the relative permittivity will have a high value. In this thesis, the effect of the imaginary part (which basically accounts for medium losses) on sensor performance and signal propagation will be analysed in detail.Although the attenuating effect the losses of this surrounding medium will have on a propagating microwave signal can be foreseen, there is still much to be learned with respect to how these dielectric properties impact the actual performance of the sensor, and how this effect may be prevented or mitigated at design stage. Furthermore, currently available set-ups to measure the performance of radiating devices have not been conceived to measure devices that do not operate in air.Bearing this in mind, this thesis intends to shed some light on the specific challenges encountered when designing devices for embedded operation in high permittivity lossy materials. This is done by means of two specific embedded application scenarios. In the first one a wireless RFID temperature sensor is placed inside a concrete structure to monitor the evolution of the setting process of concrete. Whereas in the second scenario a microwave bodyscope is used to monitor metallic implants inside the human body. Finally, in-field results are presented for both scenarios.High accuracy measurements of the evolution of concrete's relative permittivity over time and frequency are presented, which are then used as reference at sensor design stage. A specific analysis of the correlation between antenna performance and surrounding medium's dielectric properties is conducted and some preliminary design guidelines are provided. Furthermore, a novel miniaturized anechoic chamber for X-wave and embedded measurement is presented.

Last update: 06/05/2021 05:04:47.